There’s always been rumors that Agents of S.H.I.E.L.D. would tie into S.W.O.R.D. and after the AOS finale Quake aka Daisy Johnson was left in space. People are speculating once again that Quake will return in a future MCU film or Disney+ series and be a part of the S.W.O.R.D. group. The actress Chloe Bennet has always hinted that her Quake role could be brought to film since the first season of Agents.
AOS is done. Not tied into the MCU for the past few years. No characters are gonna appear in any future MCU shows or movies.
I’m with @monopolyjackson on this one. That show took place in the MCU, but the MCU never took place within it, if that makes sense. The Disney+ shows are gonna tie-in directly with the flicks, but, “Agents of S.H.I.E.L.D,” along with the Netflix shows, “Runaways,” the upcoming, “Hellstrom,” show and basically anything else is gonna be ignored and forgotten. The only real canon is the movies right now, then the Disney+ shows.